Phenolic Compounds from Antioxidant Plant Materials and their Protective Effect on PC12 cells
published in 2018. 2. 28
Abstracts
This study was designed to evaluate the antioxidant activities and protective effects on PC12 cells of the extract of Epimedium koreanum and its main constituents icariin and icariside I. After screening the seven identified flavonoid glycosides from E. koreanum through DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) assay, E. koreanum, Icariin and Icariside I exhibited significant effect on radical scavenging activity. E. koreanum, icariin and icariside I were examined using DPPH, ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) and FRAP (ferric reducing ability power) assay. In all antioxidant assays, E. koreanum, icariin and icariside I showed high radical scavenging activities in a dose-dependent manner. Protective effects against
Keyword
- Epimedium koreanum
- Antioxidant
- Icariin
- Icariside I
- PC12 cells
Chemical Compound (All 8)
Analytical Information
IPC | A61K 36/296, A61K 31/7048, A61P 39/06 |
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CPC | A61K 36/296, A61K 31/7048, A61P 39/06 |
Analytical Keyword | Epimedi Herba=Epimedium koreanum Nakai; antioxidant; phenolic compounds; water; ethanol=EtOH; MeOH=methanol; extract; DPPH radical scavenging activity; ABTS radical scavenging activity; Ferric reducing antioxidant power=FRAP; oxidative stress; icariside I; icariin; flavonoid glycosides |
Herb keywrd | Epimedi Herba=Epimedium koreanum Nakai |
Disease keywrd | antioxidant |
Etc. keywrd | phenolic compounds; water; ethanol=EtOH; MeOH=methanol; extract; DPPH radical scavenging activity; ABTS radical scavenging activity; Ferric reducing antioxidant power=FRAP; oxidative stress; icariside I; icariin; flavonoid glycosides |
KJTK Publish Information | Volume 12. 2018. 12. 31 |
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TKOI
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TKOI:KTKP-TSS-0000258676 |