Volume cover

Korean Journal of Food Culture (한국식생활문화학회지)

  • v33n1
  • pp.86-94
  • 2018
  • 1225-7060

The Korean Society of Dietary Culture (한국식생활문화학회)


Phenolic Compounds from Antioxidant Plant Materials and their Protective Effect on PC12 cells

  • You, SoHyeon (Plant Resources Research Institute, Duksung Women's University)
  • Kim, Gun-Hee (Plant Resources Research Institute, Duksung Women's University)

published in 2018. 2. 28


Abstracts

This study was designed to evaluate the antioxidant activities and protective effects on PC12 cells of the extract of Epimedium koreanum and its main constituents icariin and icariside I. After screening the seven identified flavonoid glycosides from E. koreanum through DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) assay, E. koreanum, Icariin and Icariside I exhibited significant effect on radical scavenging activity. E. koreanum, icariin and icariside I were examined using DPPH, ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) and FRAP (ferric reducing ability power) assay. In all antioxidant assays, E. koreanum, icariin and icariside I showed high radical scavenging activities in a dose-dependent manner. Protective effects against $H_2O_2-induced$ PC12 cells were assessed with MTT assay. The results indicated that cell viability and protection on PC12 cells of icariside I and icariin increased dose dependently. These study results suggest that E. koreanum, icariin and icariside showed high antioxidant capacities and cell protective effects. Icariside I, one of the metabolites of icariin, may be a new and effective flavonoid compound as a functional component.

Keyword

  • Epimedium koreanum
  • Antioxidant
  • Icariin
  • Icariside I
  • PC12 cells



Analytical Information

Analytical Information of the Articles
IPC A61K 36/296, A61K 31/7048, A61P 39/06
CPC A61K 36/296, A61K 31/7048, A61P 39/06
Analytical Keyword Epimedi Herba=Epimedium koreanum Nakai; antioxidant; phenolic compounds; water; ethanol=EtOH; MeOH=methanol; extract; DPPH radical scavenging activity; ABTS radical scavenging activity; Ferric reducing antioxidant power=FRAP; oxidative stress; icariside I; icariin; flavonoid glycosides
Herb keywrd Epimedi Herba=Epimedium koreanum Nakai
Disease keywrd antioxidant
Etc. keywrd phenolic compounds; water; ethanol=EtOH; MeOH=methanol; extract; DPPH radical scavenging activity; ABTS radical scavenging activity; Ferric reducing antioxidant power=FRAP; oxidative stress; icariside I; icariin; flavonoid glycosides

Published Information

Published Information of the Articles
KJTK Publish Information Volume 12. 2018. 12. 31
TKOI [?]

It is persistent identifier of content provided by the Korean Traditional Knowledge Portal. It is used as a permanent access route to each content.

Syntax:
http://tkoi.koreantk.com/[TKOI]
Example:
http://tkoi.koreantk.com/TKOI:KTKP-TSS-0000045749
TKOI:KTKP-TSS-0000258676