Attenuation Effect of Chamaecyparis obtusa Leaf Essential Oils on Airway Hyperresponsiveness and Airway Inflammation in Ovalbumin-Induced Murine Asthma Model

Kim, Seong Kyeom (Department of Industrial Plant Science & Technology, Chungbuk National University)
Lee, Seung Min (Department of Industrial Plant Science & Technology, Chungbuk National University)
Lim, Heung Bin (Department of Industrial Plant Science & Technology, Chungbuk National University)

published in 2015. 6. 30

Abstracts

In this study, essential oils were extracted from the leaf of Chamaecyparis obtusa (CLEO), indigenous to Korea, CLEO constituents were analysed, and the effects of CLEO on airway hyperresponsiveness (AHR) and airway inflammation (AI) were investigated in Ovalbumin (OVA)-induced asthma mouse model. Terpenoid components among identified CLEO constituents made up more than 80%. The CLEO-treated group in comparison to the control group showed reduced AHR, the decrease of eosinophil number in the bronchoalveolar lavage fluid (BALF), reduced specific anti-OVA IgE level in the serum, and a significant reduction in Th2 cytokines levels in the BALF with concentration. We concluded that CLEO have an alleviating effect on asthma-like symptoms such as AHR and AI. Further studies about antiasthmatic effect are necessary on the focus of single component of CLEO.

Keyword

Chamaecyparis obtusa
Airway Inflammation
Airway Hyperresponsiveness
Asthma
Leaf Essential Oil

Chemical Compound (All 10)

Limonene (C₁₀H₁₆)

Terpinen-4-ol (C₁₀H₁₈O)

alpha-Pinene(+,-) (C₁₀H₁₆)

Theophylline (C₇H₈N₄O₂)

2-acetoxypropyl-trimethyl-ammonium | 2-acetyloxypropyl-trimethyl-azanium | Pextin | methacholine (C₈H₁₈NO₂)

(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-keto-cyclopentyl]hept-5-enoic acid | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid | prostaglandin E2 (C₂₀H₃₂O₅)

2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate | 2-[2-[3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate | dodecanoic acid 2-[2-[3,4-bis(2-hydroxyethoxy)-2-tetrahydrofuranyl]-2-(2-hydroxyethoxy)ethoxy]ethyl ester | lauric acid 2-[2-[3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl ester (C₂₆H₅₀O₁₀)

30-ethyl-33-[(E)-1-hydroxy-2-methyl-hex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone (C₆₂H₁₁₁N₁₁O₁₂)

(3R,6S,9S,12S,15S,18R,21S,24S,30R,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methyl-hex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone (C₆₂H₁₁₁N₁₁O₁₂)

bornyacetate (C₁₂H₂₀O₂)

Analytical Information

Analytical Information of the Articles
IPC	A61K 127/00, A61K 36/14, A61P 11/06
Analytical Keyword	Chamaecyparis obtusa; airway hyperresponsiveness; airway inflammation; asthma; leaf; essential oil; ovalbumin; IgE=immunoglobulin E; Th2 cytokine; terpenoid; alpha-pinene; limonen; bornyl acetate; terpinene-4-ol; inflammation
Herb keywrd	Chamaecyparis obtusa
Disease keywrd	airway hyperresponsiveness; airway inflammation; asthma
Etc. keywrd	leaf; essential oil; ovalbumin; IgE=immunoglobulin E; Th2 cytokine; terpenoid; alpha-pinene; limonen; bornyl acetate; terpinene-4-ol; inflammation

Published Information

Cover Contents Copyright

Published Information of the Articles
KJTK Publish Information	Volume 9. 2015. 12. 31
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Korean Journal of Medicinal Crop Science (한국약용작물학회지)