Effects of Extract from Fermented Flower-buds of Panax ginseng C.A. Meyer on Mouse Cytokine IL-6, TNF-α Production

Jeong, Su-Ji (Dept. of Food & Nutrition, Chungnam National University)
Kim, Kyoung-Hee (Dept. of Food & Nutrition, Chungnam National University)
Son, Hwa-Young (College of Veterinary Medicine, Chungnam National University)
Yook, Hong-Sun (Dept. of Food & Nutrition, Chungnam National University)

published in 2014. 2. 28

Abstracts

Panax ginseng C.A. Meyer has been used as a traditional medicinal ingredient and the ginseng flower-buds also proved to have good medicinal properties. In this study, in order to enhance immune activities of ginseng flower-bud, the ginseng flower-bud extract was being fermented by Bacillus subtilis KCTC 1022 (BS), Lactobacillus plantarum KCTC3 and Saccharomyces cerevisiae strain CHY1011 (SC). Mice were orally administered daily for two weeks at two different concentrations (100 and 200 mg/kg B.W.). Treatment samples were water extracts of ginseng flower-buds (FD), water extracts of fermented ginseng flower-buds (FM) and controls for saline solution. Cytokine production (IL-6, TNF-${\alpha}$) either stimulated with LPS or not stimulated with LPS was detected by the ELISA assay when using the cytokine kit. Cytokine was statistically increased at supplemented groups with LPS in both the 100 and the 200 mg/kg B.W. and treatment with FM significantly decreased the LPS-induced TNF-${\alpha}$ and IL-6 production more than the treatment with FD. The results of this study may suggest that supplementation with FM increases the immune function by regulating cytokine production capacity for activated macrophages.

Keyword

IL-6
TNF-${\alpha}$
ginseng flower-bud
fermentation
immune cell

Chemical Compound (All 2)

(5S,8R,9R,10S,13R,14R,17R)-17-[(1R)-1,5-dimethylhexyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene | (5S,8R,9R,10S,13R,14R,17R)-4,4,8,10,14-pentamethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene | dammarane (C₃₀H₅₄)

cyclophosphamide (C₇H₁₅Cl₂N₂O₂P)

Analytical Information

Analytical Information of the Articles
IPC	A23K 10/30, A61K 133/00, A61K 36/258, A61P 37/04
Analytical Keyword	ginseng flower-bud=Flower-buds of Panax ginseng C.A. Meyer; immune enhancement; functional feed; immune cell; fermentation; IL-6=interleukin-6; macrophage; TNF-alpha=tumor necrosis factor-alpha
Herb keywrd	ginseng flower-bud=Flower-buds of Panax ginseng C.A. Meyer
Disease keywrd	immune enhancement
Etc. keywrd	functional feed; immune cell; fermentation; IL-6=interleukin-6; macrophage; TNF-alpha=tumor necrosis factor-alpha

Published Information

Cover Copyright

Published Information of the Articles
Country	kor
Publisher	The Korean Society of Food and Nutrition
KJTK Publish Information	Volume 8. 2014. 12. 31
TKOI It is persistent identifier of content provided by the Korean Traditional Knowledge Portal. It is used as a permanent access route to each content. Syntax: http://tkoi.koreantk.com/[TKOI] Example: http://tkoi.koreantk.com/TKOI:KTKP-TSS-0000045749	TKOI:KTKP-TSS-0000225600

The Korean Journal of Food And Nutrition (한국식품영양학회지)