Volume cover

The Korea Journal of Herbology (대한본초학회지)

  • v20n2
  • pp.91-102
  • 2005

The Korea Association of Herbology (대한본초학회)


The Effects of Jwa Kum-Whan and Soo Ryeon-Whan on the Hyperlipidemia in Rats

  • Kim, Yi-Heon (金利眩; Dept. of Herbology, College of Oriental Medicine, Kyungwon University)
  • Seong, Nak-Sul (成洛戌; National Crop Experiment Station, RDA)
  • Lee, Young-Jong (李映鍾; Dept. of Herbology, College of Oriental Medicine, Kyungwon University)

published in 2005. 6.


Abstracts

Objectives : By examining the effects of Jwa Kum-Whan composed of Coptidis Rhizoma and Evodiae Fructus by the ratio of 6:1 the effects of Soo Ryeon-Whan and composed of Coptidis Rhizoma and Evodiae Fructus by the ratio of 1:1 on hyperlipidemia, the present study attempted to reveal the change of effects based on the ratio of combination. Methods : Jwa Kum-Whan and Soo Ryeon-Whan were injected to rats suffered from induced hyperlipidemia, and then its influence on lipid. During the cultivation of hepatocytes, Jwa Kum-Whan and Soo Ryeon-Whan were added to culture media, and the expression of the enzymes relevant to fat metabolism of hepatocytes was examined. Results : 1. Jwa Kum-Whan significantly decreased total cholesterol(Tc), triglyceride(TG), and LDL-cholesterol(LDLc) of rats suffering from hyperlipidemia induced by high cholesterol diet. Soo Ryeon-Whan decreased LDLc, but had no significant on Tc and TG. 2. Jwa Kum-Whan increased the expression of cholesterol esterase, LDL-receptor, diacylglycerol acyltransferase (DGAT), acylCoA-cholesterol-acyltransferase (ACAT), peroxisome proliferator activated receptor gamma $(PPAR{\gamma})$, peroxisome proliferator activated receptor alpha $(PPAR{\alpha})$ of cultivated hepatocytes. In addition, Soo Ryeon-Whan increased the expression of cholesterol esterase, LDL-Receptor, DGAT, $PPAR{\gamma},\;PPAR{\alpha}$ of cultivated hepatocytes, but had no significant effects on the expression of ACAT. Conclusion : Both Jwa Kum-Whan and Soo Ryeon-Whan were composed of Coptidis Rhizoma and Evodiae Fructus, but the fonner is more effective in hyperlipidemia.

Keyword

  • Jwa Kum-Whan
  • Soo Ryeon-Whan
  • Coptidis Rhizoma
  • Evodiae Fructus
  • hyperlipidemia


Analytical Information

Analytical Information of the Articles
IPC A61K 36/718, A61K 36/754, A61P 3/06
Analytical Keyword Coptidis Rhizoma=Coptis chinensis Franch; Evodiae Fructus=Evodia rutaecarpa Benth.; hyperlipidemia; Jwa Kum-Whan; Soo Ryeon-Whan; total cholesterol(Tc); triglyceride(TG); LDL-cholesterol; high cholesterol diet
Herb keywrd Coptidis Rhizoma=Coptis chinensis Franch; Evodiae Fructus=Evodia rutaecarpa Benth.
Prescription keywrd Jwa Kum-Whan; Soo Ryeon-Whan
Disease keywrd hyperlipidemia
Etc. keywrd total cholesterol(Tc); triglyceride(TG); LDL-cholesterol; high cholesterol diet
Related Herbs (All 164건) Gyeonyuk(犬肉); Goda(苦茶); Goga(穀芽)A; Gongpohwang(貢蒲黃); Gwache(瓜蒂); Gwachemal(瓜蒂末); Gu(狗); Gu(蛷); Gu(韭); Guchae(韭菜); Gupihyejeo(久皮鞋底); Geumbak(金箔); Geumseonwa(金線蛙)A; Geumseonwa(金線蛙)B; Geumseonwa(金線蛙)C

Published Information

Published Information of the Articles
Country kor
Publisher The Korea Association of Herbology
Language Korean
KJTK Publish Information Volume 1. 2007. 12. 28
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