Anti-oxidant and Anti-aging Activities of Essential Oils of Pinus densiflora Needles and Twigs
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Kim, Youn-Joung
(Division of Pathophysiology College of Pharmacy Chung-Ang University)
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Cho, Bong-Jae
(Division of Pathophysiology College of Pharmacy Chung-Ang University)
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Ko, Myung-Soo
(Division of Pathophysiology College of Pharmacy Chung-Ang University)
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Jung, Jae-Min
(Division of Pathophysiology College of Pharmacy Chung-Ang University)
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Kim, Hee-Rae
(Division of Pathophysiology College of Pharmacy Chung-Ang University)
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Song, Ho-Sun
(Division of Pathophysiology College of Pharmacy Chung-Ang University)
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Lee, Ji-Yun
(Division of Pathophysiology College of Pharmacy Chung-Ang University)
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Sim, Sang-Soo
(Division of Pathophysiology College of Pharmacy Chung-Ang University)
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Kim, Chang-Jong
(Division of Pathophysiology College of Pharmacy Chung-Ang University)
published in 2010. 8. 31
Abstracts
To investigate effects of pine essential oil isolated by steam distillation from Pinus densiflora needles (PN) and twigs (PT) on anti-oxidant and anti-aging activities, the experiments were carried out to determine anti-oxidant and antiaging activities on DPPH radical scavenging activity, NBT/xanthine oxidase-superoxide scavenging activity, silica-induced intracellular $H_2O_2$ and hydroxyl radical generation in RAW264.7 cells, hyaluronidase and elastase activities in vitro. Essential oil of PN and PT were contained 0.225 and 0.176 (w/v) %, respectively. PN was contained with 30 kinds of essential oil and its major constituent is $\alpha$-pinene (21.5%). Further PT was contained with 40 kinds of essential oil and its major constituent is $\beta$-pinene (22.4%) in GC/MS assay. Other essential oils of PN were $\beta$-pinene, camphene, myrcene, limonene, terpinolene, $\alpha$-terpineol, bornyl acetate, $\alpha$-copaene, caryophellene and humulene and PT were $\alpha$-pinene, camphene, phellandrene, limonene, terpinolene, $\alpha$-terpineol, bornyl acetate, $\alpha$-copaene, caryophellene and humulene. The essential oil of PT have more active than that of PN in anti-oxidant activity which has significant DPPH radical and superoxide scavenging activity, and significant inhibitory activities on silica-induced intracellular $H_2O_2$ and hydroxyl radical generation, as well as, significantly inhibited elastase and hyaluronidase activities. Further, phellandrene, myrcene and $\alpha$-pinene have DPPH radical and superoxide scavenging activities, $\beta$-pinene, terpinolene, myrcene and phellandrene inhibited silica-induced intracellular $H_2O_2$ and hydroxyl radical generations. And also phellandrene and $\beta$-pinene inhibited hyaluronidase and elastase activities. In conclusion, the essential oils isolated from PN and PT have anti-oxidant and anti-aging activities.
Keyword
- pinus essential oil
- superoxide
- hydroxyl radical
- hyaluronidase
Chemical Compound
(All 25)
Analytical Information
Analytical Information of the Articles
IPC |
A61K 8/97, A61K 36/15, A61K 127/00, A61K 135/00, A61P 39/06, A61Q 19/08 |
Analytical Keyword |
Pinus densiflora; anti-oxidant; anti-aging; essential oil; needle; twig; DPPH=1,1-diphenyl-2-picrylhydrazyl; nitroblue tetrazolium=NBT; xanthine oxidase; hyaluronidase; elastase; hydrogen peroxide=H2O2; hydroxyl radical; α-pinene; camphene; β-pinene; myrcene; phellandrene; terpinolene; cosmetics
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Herb keywrd |
Pinus densiflora
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Disease keywrd |
anti-oxidant; anti-aging
|
Etc. keywrd |
essential oil; needle; twig; DPPH=1,1-diphenyl-2-picrylhydrazyl; nitroblue tetrazolium=NBT; xanthine oxidase; hyaluronidase; elastase; hydrogen peroxide=H2O2; hydroxyl radical; α-pinene; camphene; β-pinene; myrcene; phellandrene; terpinolene; cosmetics
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Published Information of the Articles
Country |
kor |
Publisher |
The Pharmaceutical Society of Korea |
Language |
Korean |
KJTK Publish Information |
Volume 4.
2010. 12. 31
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