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The Korean Journal of Mycology (한국균학회지)

  • v38n2
  • pp.167-171
  • 2010
  • 0253-651X

The Korean Society of Mycology (한국균학회)

Inhibitory Effects of Melanin Secretion on B16 Melanoma cell of Cordyceps militaris Water Extract

  • Nam, Byung-Hyouk (Department of Microbiology, College of Natural Sciences, Pusan National University)
  • Jo, Wool-Soon (Dong Nam Institute of Radiological & Medical Sciences)
  • Choi, Yoo-Jin (Dong Nam Institute of Radiological & Medical Sciences)
  • Lee, Jae-Yun (Department of Microbiology, College of Natural Sciences, Pusan National University)
  • Kang, Eun-Young (Busan Techno-park Marine Bio-Industry Development Center)
  • Jeong, Min-Ho (Department of Microbiology, Dong-A University Medical College)
  • Lee, Jae-Dong (Department of Microbiology, College of Natural Sciences, Pusan National University)

published in 2010. 12. 31

Abstracts

The present study aims to evaluate Cordyceps militaris water extract (CMWE) with a view to develop melanogenesis inhibitors. Inhibitory activities of CMWE against tyrosinase, L-DOPA(L-3,4-dihydroxyphenylalanine) oxidation, and melanin biosynthesis in B16 mouse melanoma cells were investigated. CMWE, at $5000\;{\mu}g/ml$, inhibited tyrosinase activity of 71% and DOPA oxidation of 40% as reacting with L-DOPA. Furthermore, B16 mouse melanoma cell survived over 50% from low to high dose on MTT assay, and CMWE markedly inhibited (> 50%) melanin synthesis at $5000\;{\mu}g/ml$. The inhibitory effect of CMWE on melanogenesis was attributed to enhancement of tyrosinase degradation. Key enzyme of melanin biosynthesis is tyrosinase which catalyses a beginning step from tyrosine to DOPA quinine and melanin formation step, respectively. These results indicated that CMWE may be a potential source of novel whitening agents for cosmetic or therapeutic application.

Keyword

  • Melanogenesis
  • Melanoma
  • Militaris
  • Tyrlsinase
  • Whitening

Chemical Compound (All 9)

Vitamin A (C20H30O)
(-)-Tyrosine (S-form) (C9H11NO3)
(2R)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid | (2R)-2-amino-3-(3,4-dihydroxyphenyl)propionic acid | L-3,4-dihydroxyphenyl-alanine (C9H11NO4)
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol | (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydropyran-3,4,5-triol | (2S,3R,4S,5S,6R)-2-(4-hydroxyphenoxy)-6-methylol-tetrahydropyran-3,4,5-triol | arbutin (C12H16O7)
5,6-dihydroxy-2,3-dihydro-1H-indole-2-carboxylate | 5,6-dihydroxy-2-indolinecarboxylate | 5,6-dihydroxyindoline-2-carboxylate (C9H8NO4)
DOPA chrome (C9H7NO4)
5,6-dihydroxyindole carboxylic acid (C9H7NO4)
DOPA quinone (C9H9NO4)
L-tyrosine (C9H11NO3)

Analytical Information

Analytical Information of the Articles
IPC A61K 8/97, A61K 36/068, A61Q 19/02, A61P 17/00
Analytical Keyword Cordyceps militaris; melanogenesis; tyrosinase; whitening; melanin; hot water; extract; L-DOPA=L-3,4-dihydroxyphenylalanine; melanoma; cosmetic
Herb keywrd Cordyceps militaris
Disease keywrd melanogenesis
Etc. keywrd tyrosinase; whitening; melanin; hot water; extract; L-DOPA=L-3,4-dihydroxyphenylalanine; melanoma; cosmetic

Published Information

Cover Contents
Published Information of the Articles
Country kor
Publisher The Korean Society of Mycology
Language Korean
KJTK Publish Information Volume 5. 2011. 12. 31
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